Melanotan 2 South Africa
Melanotan II (Melanotan 2) is a produced modification of a peptide hormone that’s produced in your body and stimulates melanogenesis, which is a process that’s responsible for pigmentation of your skin. This peptide hormone, known as an α-melanocyte-stimulating hormone or α-MSH, activates some melanocortin receptors while applying its effects.
Also, melanocyte-stimulating hormone exerts potent influence over sexual libido, appetite, and lipid metabolism. So, Melanotan II has proven in studies to exhibit libido-enhancing, appetite suppressant, and lipolytic effects on top of promoting skin tanning.
It hasresearched for use protection against ultraviolet radiation harmful effects from the sun’s rays due to its amazing melanogenesis-stimulating properties. Also, Melanotan II and a produced variant that’s similar (PT-141) studied in detail as a potential treatment for sexual dysfunction (sexual malfunction, especially male ED (erectile dysfunction).
Melanotan 2 Development
The initial synthetic Melanotan 2 peptide creation can all credited to the UA (University of Arizona), a public research university. During study aimed at developing a defense against skin cancer, the focus put on developing a way of stimulating the natural melanin production in the skin, or natural melanogenesis, without direct exposure to ultraviolet radiation in sunlight, which are harmful.
, UA researchers tried administering the occurring hormone, melanocyte-stimulating hormone, to elicit the desired result. Although the strategy showed promising outcomes, it discovered that this occurring melanocyte-stimulating hormone had a very short half-life considered of practical use as a curative remedy.
The positive results, but, gleaned from melanocyte-stimulating hormone administration encouraged more research into the Melanotan 1 plus Melanotan 2 development, which exhibits similar effects while possessing a half-life that’s extended for functional therapeutic use.
Studies and Further Information on Melanotan 2
Melanotan and Melanotan II are all analogs of the peptide hormone α-MSH (α-melanocyte-stimulating hormone) that tend to be inducing skin tanning. Mel2, unlike Melanotan 1, proven to have aphrodisiac properties, which is the more positive effect of increasing sex drive (libido). MkII is a cyclic heptapeptide analog of the α-MSH (α-melanocyte-stimulating hormone).
Also, Melanotan 2 effects on the food intake and diet of the lab mice investigated. It’s shown that Melanotan 2 has activated the MC (central melanocortin) when induced and fed to the mice. The 6-day treatment of Melanotan II has revealed that the peptide reduced the adipose tissue and body weight in the mice’s viscera and suppressed the organism’s intake of calories.
That has indications in the clinical use of the possible treatment of reducing calorie or carbohydrate intake, especially for the obese and the overweight. Moreover, the same study showed that there was a continued increase in the available consumption of oxygen in animals that are obese.
Also, Melanotan II helped in reducing serum insulin levels and the levels of cholesterol more than control treatments. Moreover, suggested that Melanotan II lowers acetylcholine (ACh) A carboxylase expression and also prevent palmitoyltransferase I mRNA and carnitine reduction in muscle-type tissues through pair-feeding in the obese rats’ muscles. Furthermore, Melanotan II peptides indeed increased fat catabolism in muscles and also improved cholesterol metabolism.
α-MSH Analogues (Melanotan Peptides)
α-MSH (α-Melanocyte-stimulating hormone) is an endogenous Melanotan peptide hormone that belongs to the melanocortin family and occurs and regarded as the most important one of the MSH in melanogenesis stimulation, a process in mammals that’s responsible for skin and hair pigmentation.
Also, the α-Melanocyte-stimulating hormone plays a role in energy homeostasis, feeding behavior, and sexual activity (Melanotan 2 and Bremelanotide). the α-Melanocyte-stimulating hormone known to be a nonselective agonist of the melanocortin receptors MC5, MC4, MC3, and MC1. Melanotan 2 and Melanotan 1 activate the MC1 receptor, responsible for the effects on skin pigmentation.
Several synthetic analogs of the α-melanocyte-stimulating hormone have studied for their photoprotective effects against UV (ultraviolet) radiation from sunlight, afamelanotide (Melanotan) and Melanotan 2 (Melanotan II).
Bremelanotide, which is another analog of an α-melanocyte-stimulating hormone-like Melanotan II, is under development for sexual dysfunction treatment. All these Melanotan peptides have higher potencies than an α-melanocyte-stimulating hormone, but with unique selectivity peptide profiles.
Purchase PT-141, Melanotan and Melanotan at Online Supplier
Direct Peptides South Africa , the leading supplier of Melanotan, is offering a wide variety of premium qualityα-melanocyte-stimulating hormone analogs tested at 99 percent least purity. We understand the significance of buying only Melanotan peptides of the highest quality online to guarantee purity and greatest potency (stability) of your PT-141, Melanotan ,2 and Melanotan 1 when you shop online.
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